使用本公司 MCAO 栓线发表的部分英文论文（至 2019 年 4 月） （论文中检索到的“Beijing Cinontech Co. Ltd.”或“Beijing Sunbio Biotech Co. Ltd.”都 是指使用本公司栓线产品） 

1. Dong B, et al. Hemopexin alleviates cognitive dysfunction after focal cerebral ischemia-reperfusion injury in rats. BMC Anesthesiol. 2019; 19: 13. Published online 2019 Jan 15. doi: 10.1186/s12871-019-0681-2. 

2. He H, et al. Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke. Neural Regen Res. 2019 Feb; 14(2): 280–288. 

3. Ran Y, et al. Splenectomy Fails to Provide Long-Term Protection Against Ischemic Stroke. Aging Dis. 2018 Jun; 9(3): 467–479. 

4. Li X, et al. Intranasal administration of nerve growth factor promotes angiogenesis via activation of PI3K/Akt signaling following cerebral infarction in rats. Am J Transl Res. 2018; 10(11): 3481–3492. 

5. Lin X, et al. iTRAQ-Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke. Biomed Res Int. 2018; 2018: 6920213. 

6. Xu F, et al. Brain-Derived Glia Maturation Factor β Participates in Lung Injury Induced by Acute Cerebral Ischemia by Increasing ROS in Endothelial Cells. Neurosci Bull. 2018 Dec; 34(6): 1077–1090. 

7. Bi M, et al. Bone mesenchymal stem cells transplantation combined with mild hypothermia improves the prognosis of cerebral ischemia in rat. PLoS One. 2018; 13(8): e0197405. 

8. Qu B, et al. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway. Evid Based Complement Alternat Med. 2018; 2018: 7290170. 

9. Zheng X, et al. Buyang Huanwu Decoction Targets SIRT1/VEGF Pathway to Promote Angiogenesis After Cerebral Ischemia/Reperfusion Injury. Front Neurosci. 2018; 12: 911. 

10. Yao G, et al. Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia. Cell Death Dis. 2018 Oct; 9(10): 1033. 

11. Gong Z, et al. Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury. J Neuroinflammation. 2018; 15: 242. 

12. He Y, et al. Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling. J Cereb Blood Flow Metab. 2017 Aug; 37(8): 2938–2951. 

13. Wang Z, et al. Phosphorylation at S153 as a Functional Switch of Phosphatidylethanolamine Binding Protein 1 in Cerebral Ischemia-Reperfusion Injury in Rats. Front Mol Neurosci. 2017; 10: 358. 

14. Guo C, et al. The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury. Sci Rep. 2017; 7: 3039. 

15. Guo C, et al. The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury. Sci Rep. 2017; 7: 3039. 

16. Wu R, et al. TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain. 2017; 10: 20. 

17. Yu HY, et al. Comparison of the glycopattern alterations of mitochondrial proteins in cerebral cortex between rat Alzheimer’s disease and the cerebral ischemia model. Sci Rep. 2017; 7: 39948. 

18. Zhang Q, et al. Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis. Front Pharmacol. 2017; 8: 165. 

19. Zhang Q, et al. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxid Med Cell Longev. 2017; 2017: 9848594. Published online 2017 Aug 14. doi: 10.1155/2017/9848594. 

20. Zhang XH, et al. Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds. Front Pharmacol. 2017; 8: 452. 

21. Liu XM, et al. Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats. BMC Complement Altern Med. 2017; 17: 8. 

22. Hu Y, et al. Microarray expression profiles of genes in lung tissues of rats subjected to focal cerebral ischemia-induced lung injury following bone marrow-derived mesenchymal stem cell transplantation. Int J Mol Med. 2017 Jan; 39(1): 57–70. 

23. Yao YG, et al. MG53 permeates through blood-brain barrier to protect ischemic brain injury. Oncotarget. 2016 Apr 19; 7(16): 22474–22485. 

24. Li YT, et al. Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula. Molecules 2016, 21(9), 1191. 

25. Min XL, et al. MicroRNAs: a novel promising therapeutic target for cerebral ischemia/reperfusion injury? Neural Regen Res. 2015 Nov; 10(11): 1799–1808. 

26. Lin J, Zheng C, Zhang X, et al. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evidence-Based Complementary and Alternative Medicine. Volume 2015, Article ID 394926, 10 pages. 

27. Lian T, Qu D, Zhao X, et al. Identification of Site-Specific Stroke Biomarker Candidates by Laser Capture Microdissection and Labeled Reference Peptide. Int. J. Mol. Sci. 2015, 16, 13427-13441. 

28. Lin M, Sun W, Gong W, et al. Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro. PLOS ONE, April 21, 2015. 

29. Zhou F, Gao S, Wang L, et al. Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. Stem Cell Research & Therapy (2015) 6:92. 

30. Wen Y, Zhang X, Dong L, et al. Acetylbritannilactone Modulates MicroRNA-155-Mediated Inflammatory Response in Ischemic Cerebral Tissues. Mol Med. 2015; 21(1): 197–209. 

31. Yao H, Gao M, Ma J, et al. Transdifferentiation-Induced Neural Stem Cells Promote Recovery of Middle Cerebral Artery Stroke Rats. PLoS One. 2015; 10(9): e0137211. 

32. Fang L, Gao H, Zhang W, et al. Resveratrol alleviates nerve injury after cerebral ischemia and reperfusion in mice by inhibiting inflammation and apoptosis. Int J Clin Exp Med. 2015; 8(3): 3219–3226. 

33. Hua K, Sheng X, Li TT, et al. The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats. Acta Pharmacol Sin. 2015 Aug; 36(8): 917–927. 

34. Lan Z, Xu X, Xu W, et al. Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug Des Devel Ther. 2015; 9: 3377–3391. 

35. Li X, Li C, Wei LY, et al. Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats. Neural Regen Res. 2015 Jun; 10(6): 932–937. 

36. Jiang M, Li J, Peng Q, et al . Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation. 2014; 11: 167. 

37. Feng R, et al. Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats. Exp Ther Med. 2014 Oct; 8(4): 1325–1329. 

38. Zhao G, et al. Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area. Molecules. 2014 Oct; 19(10): 15786–15798. 

39. Nie B, et al. A Statistical Parametric Mapping Toolbox Used for Voxel-Wise Analysis of FDG-PET Images of Rat Brain. PLoS One. 2014; 9(9): e108295. 

40. Wang Z, et al. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury. Evid Based Complement Alternat Med. 2014; 2014: 430757. 

41. Yu S, et al. An Active Component of Achyranthes bidentataPolypeptides Provides Neuroprotection through Inhibition of Mitochondrial-Dependent Apoptotic Pathway in Cultured Neurons and in Animal Models of Cerebral Ischemia. PLoS One. 2014; 9(10): e109923. 

42. Sun J, et al. Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression. Biomed Res Int. 2014; 2014: 925762. 

43. Li H, et al. Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice. Neurobiol Dis. 2013 Jun; 54: 216–224. 

44. Zhang N, et al. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice. Mediators Inflamm. 2014; 2014: 370530. 

45. Luo Y, Yang YP, Li WH, et al. Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. Brain Research. Available online 13 April 2014. 

46. Wang ZX, Huang WQ, Zuo ZY. Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat. Journal of Neuroinflammation 2014, 11:56. 

47. Sun L, Qiang R, Yang Y, et al. L-Serine Treatment May Improve Neurorestoration of Rats after Permanent Focal Cerebral Ischemia Potentially Through Improvement of Neurorepair. PLoS ONE 2014, 9(3): e93405. doi: 10.1371/journal.pone.009340. 

48. Li L, et al. Glutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice. Brain Res Bull. 2013 Sep; 98: 23–29. 

49. Zhu X, et al. Electroacupuncture preconditioning-induced neuroprotection may be mediated by glutamate transporter type 2. Neurochem Int. 2013 Oct; 63(4): 302–308. 

50. Lin Y, Zhang JC, Fu J, et al. Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 253–262; 

51. An S, Kuang YY, Shen T, et al. Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury. Biomaterials 34 (2013) 8949-8959. 

52. Fu J, Xue R, Gu JF, et al. Neuroprotective effect of calcitriol on ischemic/reperfusion injury through the NR3A/CREB pathways in the rat hippocampus. Molecular Medicine Reports. 2013, 1708-1714. 

53. Cheng FF, Lu Y, Zhong XG. Baicalin's Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine, vol.2013, PP.1-11, 2013. 

54. Chen XY, Sun XC, Su HX. Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats. BMC Neuroscience, 2013, 14:56. 

55. Dong BB, Cai M, Fang ZP. Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia. BMC Neuroscience 2013, 14:58. 

56. Lan R, Xiang J, Zhang Y. PI3K/Akt Pathway Contributes to Neurovascular Unit Protection of Xiao-Xu-Ming Decoction against Focal Cerebral Ischemia and Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine, Volume 2013. 

57. Li JJ, Sheng WL, Feng CZ. Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia. Neurobiol Dis. 2012; 45(1): 564–572. 

58. Guo JY, Ding J, Yuan F. Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Int. J. Mol. Sci. 2013, 14, 12013-12022. 

59. Li LL, Zuo ZY. Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability. Neuroscience. 2011 December 29; 199: 44–50. 

60. Li H, Yin JB, Li LL, et al. Isoflurance postconditioning reduces ischemia-induced nuclear factor-kB activation and interleukin 1β production to provide neuroprotection in rats and mice. Neurobiology of Disease. Available online 8 January 2013. 

61. Zhu SP, Li Y, Lu HY, et al. Imaging the Early Cerebral Blood Flow Changes in Rat Middle Cerebral Artery Occlusion Stroke Model. 34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August - 1 September, 2012. 

62. Cheng FF, Zhong XG, Lu Y, et al. Refined Qingkailing ProtectsMCAOMice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 567872, 12 pages. 

63. Zhai FG, Zhang XP, Guan Y, et al. Expression profiles of microRNAs after focal cerebral ischemia/reperfusion injury in rats. Neural Regen Res. 2012; 7(12):917-923. 

64. Li LL, Zuo ZY. Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. Journal of Cerebral Blood Flow & Metabolism . 2011; 31:1283-1292. 

65. Ding H, Yan C-Z, Shi H, Zhao Y-S, Chang S-Y, et al. Hepcidin Is Involved in Iron Regulation in the Ischemic Brain. PLoS ONE.2011, 6(9): e25324. 

66. Han QQ, Li B, Feng H, et al. The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials. 2011; 32(22):5077-5085. 

67. Xu HY, Zhang CW, Zhang CX. Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion. Neural Regen Res. 2011;6(14):1086-1090. 

68. Liu K, Li Z, Wu T, et al. Role of Rho Kinase in Microvascular Damage Following Cerebral Ischemia Reperfusion in Rats. Int. J. Mol. Sci. 2011; 12: 1222-1231. 

69. Yang L, Zhang BS, Yin L, et al. Tanshinone IIA Prevented Brain Iron Dyshomeostasis in Cerebral Ischemic Rats. Cell Physiol Biochem, 2011; 27:23-30. 

70. Sun L, Ai J, Wang N, et al. Cerebral Ischemia Elicits Aberration in Myocardium Contractile Function and Intracellular Calcium Handling. Cell Physiol Biochem 2010; 26:421-430. 

71. Zhang F, Wu Y, Jia J et al. Pre-Ischemic Treadmill Training Induces Tolerance to Brain Ischemia: Involvement of Glutamate and ERK1/2. Molecules. 2010；15： 5246-5257. 

72. Wu Y, Ye XH, Guo PP, et al. Neuroprotective Effect of Lipoxin A4 Methy Ester in a Rat Model of Permanent Focal Cerebral Ischemia. J Mol Neurosci. 2010; 22:226-234. 

73. Li LL, Zuo ZY. Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. J Neuroscience.2009; 164:497-506. 

74. Xing BZ, Chen H, Zhang M. PhD. Ischemic Postconditioning Inhibits Apoptosis after Focal Cerebral Ischemia/Reperfusion Injury in the Rat. Stroke. 2008; 39:2362-2369. 

75. Xing BZ, Chen H, Zhang M, et al. Ischemic post-conditioning protects brain and reduces inflammation in a rat model of focal cerebral ischemia/reperfusion. Journal of Neurochemistry. 2008; 105(5):1737-1745.